First-trimester circulating 25-hydroxyvitamin D levels and development of gestational diabetes mellitus

Makgoba, M., Nelson, S.M. , Savvidou, M., Messow, C.-M. , Nicolaides, K. and Sattar, N. (2011) First-trimester circulating 25-hydroxyvitamin D levels and development of gestational diabetes mellitus. Diabetes Care, 34(5), pp. 1091-1093. (doi: 10.2337/dc10-2264)

Abstract

OBJECTIVE-To investigate the association between first-trimester maternal serum levels of 25-hydroxyvitamin D (25-OH-D) as measured by liquid chromatography-tandem mass spectrometry and development of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS-We conducted a case-control study involving 248 women in the first-trimester of pregnancy, 90 of whom developed GDM and 158 remained normoglycemic. RESULTS-Although booking 25-OH-D levels correlated negatively with 2-h glucose postoral glucose tolerance test and positively with HDL cholesterol, as well as with ethnicity, obesity, and smoking (all P < 0.05), there were no statistically significant differences in baseline maternal mean 25-OH-D levels between those who subsequently developed GDM, 18.9 ng/mL (SD 10.7) and those who remained normoglycemic, 19.0 ng/mL (10.7) (P = 0.874), even after adjustment for possible confounders including sampling month (P = 0.784). CONCLUSIONS-Our large and well-phenotyped prospective study did not find evidence of an association between first-trimester maternal levels of 25-OH-D and subsequent development of GDM.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Nelson, Professor Scott and Messow, Dr Martina and Sattar, Professor Naveed
• Authors: Makgoba, M., Nelson, S.M., Savvidou, M., Messow, C.-M., Nicolaides, K., and Sattar, N.
• College/School: College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre; College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Diabetes Care
• ISSN: 0149-5992