Correcting for multivariate measurement error by regression calibration in meta-analyses of epidemiological studies

Shepherd, J., Lowe, G., Ford, I. and Robertson, M. (2009) Correcting for multivariate measurement error by regression calibration in meta-analyses of epidemiological studies. Statistics in Medicine, 28(7), pp. 1067-1092. (doi: 10.1002/sim.3530)

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Within-person variability in measured values of multiple risk factors can bias their associations with disease. The multivariate regression calibration (RC) approach can correct for such measurement error and has been applied to studies in which true values or independent repeat measurements of the risk factors are observed on a subsample. We extend the multivariate RC techniques to a meta-analysis framework where multiple studies provide independent repeat measurements and information on disease outcome. We consider the cases where some or all studies have repeat measurements, and compare study-specific, averaged and empirical Bayes estimates of RC parameters. Additionally, we allow for binary covariates (e.g. smoking status) and for uncertainty and time trends in the measurement error corrections. Our methods are illustrated using a subset of individual participant data from prospective long-term studies in the Fibrinogen Studies Collaboration to assess the relationship between usual levels of plasma fibrinogen and the risk of coronary heart disease, allowing for measurement error in plasma fibrinogen and several confounders.

Item Type:Articles (Editorial)
Additional Information:<p>Glasgow authors part of <b>The Fibrinogen Studies Collaboration (FSC)</b></p> <p><b>Authors/Writing Committee of the Fibrinogen Studies Collaboration:</b> <br>A. M. Wood, I. R. White, S. G. Thompson.</br></p> <p><b>Authors/Members of the Fibrinogen Studies Collaboration:</b> <br><i>Aspirin Myocardial Infarction Study:</i> J. B. Kostis, A. C. Wilson; Atherosclerosis Risk in Communities Study: K. Wu; <i>Bezafibrate Infarction Prevention Study</i>: M. Benderly, U. Goldbourt; Bruneck Study: J. Willeit, S. Kiechl; Caerphilly Study: J. W. G. Yarnell, P. M. Sweetnam, P. C. Elwood; <i>Cardiovascular Health Study</i>: M. Cushman, R. P. Tracy (see for acknowledgments); <i>Copenhagen City Heart Study</i>: A. Tybjærg-Hansen; <i>European Concerted Action on Thrombosis and Disabilities (ECAT) Angina Pectoris Study</i>: F. Haverkate, S. G. Thompson; <i>Edinburgh Artery Study and Edinburgh Claudication Study</i>: A. J. Lee, F. B. Smith; <i>Finnish National Risk Factor Survey 1992, Hemostasis Study</i>: V. Salomaa, K. Harald, V. Rasi, P. Jousilahti, J. Pekkanen; Framingham Study: R. D’Agostino, P. W. F. Wilson, G. Tofler, D. Levy; <i>GISSI-Prevenzione Trial</i>: R. Marchioli, F. Valagussa (deceased); <i>G¨oteborg 1913 and G¨oteborg 1933 studies</i>: A. Rosengren, G. Lappas, H. Eriksson; <i>G¨ottingen Risk Incidence and Prevalence Study</i>: P. Cremer, D. Nagel; Honolulu Heart Program: J. D. Curb, B. Rodriguez, K. Yano; <i>Kuopio Ischaemic Heart Disease Study</i>: J. T. Salonen, K. Nyyss¨onen, T.-P. Tuomainen; Malm¨o Study: B. Hedblad, G. Engstr¨om, G. Berglund; <i>MONICA/KORA Augsburg Study</i>: H. Loewel, H. W. Hense; <i>Northwick Park Heart Study I</i>: T. W. Meade, J. A. Cooper, B. De Stavola, C. Knottenbelt; <i>Northwick Park Heart Study II</i>: G. J. Miller (deceased), J. A. Cooper, K. A. Bauer, R. D. Rosenberg; <i>Osaka Study</i>: S. Sato, A. Kitamura, Y. Naito, H. Iso; <i>Platelet Activation and Inflammation Study</i>: V. Salomaa, K. Harald, V. Rasi, E. Vahtera, P. Jousilahti, T. Palosuo; <i>Prospective Epidemiological Study of Myocardial Infarction</i>: P. Ducimetiere, P. Amouyel, D. Arveiler, A. E. Evans, J. Ferrieres, I. Juhan-Vague, A. Bingham; <i>Prospective Cardiovascular M¨unster Study</i>: H. Schulte, G. Assmann; <i>Quebec Cardiovascular Study</i>: B. Cantin, B. Lamarche, J.-P. Despr´es, G. R. Dagenais; <i>Scottish Heart Health Study</i>: H. Tunstall-Pedoe, G. D. O. Lowe, M. Woodward; Speedwell Study: Y. Ben-Shlomo, G. Davey Smith; <i>Strong Heart Study</i>: V. Palmieri, J. L. Yeh; <i>Thrombosis Prevention Trial</i>: T. W. Meade, P. Brennan, C. Knottenbelt, J. A. Cooper; <i>Physicians’ Health Study</i>: P. Ridker; Vicenza <i>Thrombophilia and Atherosclerosis Project</i>: F. Rodeghiero, A. Tosetto; <i>West of Scotland Coronary Prevention Study</i>: J. Shepherd, G. D. O. Lowe, I. Ford, M. Robertson; <i>Whitehall II Study</i>: E. Brunner, M. Shipley; <i>Zutphen Elderly Study</i>: E. J. M. Feskens, D. Kromhout.</br></p> <p><b>Authors/Coordinating Centre of the Fibrinogen Studies Collaboration</b>: <br>E. Di Angelantonio, S. Kaptoge, S. Lewington, G. D. O. Lowe, N. Sarwar, S. G. Thompson, M. Walker, S. Watson, I. R. White, A. M. Wood, J. Danesh (coordinator).</br></p> <p>Conflict of interest: none declared.</p> <p>The following FSC investigators contributed data to the current study but did not participate as co-authors: <br>A. R. Folsom, L. Chambless, B. M. Psaty, M. P. M. de Maat, F. G. R. Fowkes, E. Vahtera, W. B. Kannel, L. Wilhelmsen, W. Koenig, A. Rudnicka.</br></p>
Keywords:measurement error; within-person variation; meta-analysis; individual participant data; regression calibration
Glasgow Author(s) Enlighten ID:Robertson, Mrs Michele and Shepherd, Prof James and Lowe, Professor Gordon and Ford, Professor Ian
Authors: Shepherd, J., Lowe, G., Ford, I., and Robertson, M.
Subjects:R Medicine > R Medicine (General)
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
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College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Statistics in Medicine
Publisher:John Wiley & Sons Ltd.
ISSN (Online):1097-0258
Published Online:16 February 2009

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