MacKay, G. J., Molloy, R.G. and O'Dwyer, P.J. (2011) C-reactive protein as a predictor of postoperative infective complications following elective colorectal resection. Colorectal Disease, 13(5), pp. 583-587. (doi: 10.1111/j.1463-1318.2010.02236.x)
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Publisher's URL: http://dx.doi.org/10.1111/j.1463-1318.2010.02236.x
Abstract
Aim: C-reactive protein (CRP) may be useful in predicting postoperative complications. We investigated the sensitivity and specificity of postoperative CRP for infective complications after elective colorectal surgery. Method: One hundred and sixty consecutive patients (72 years old; interquartile range, 63-79) undergoing elective resection for colorectal cancer treated between September 2003 and October 2006 were studied. Details of the postoperative course were prospectively entered into a database. Of the 160 patients, 10 had incomplete CRP data and were excluded from further analysis. Results: Infective complications occurred in 21%, with an overall complication rate of 29%. Infective complications occurred as follows: respiratory (10), wound (9), urinary tract (2) and central line infection (1), anastomotic leakage (5), intra-abdominal abscess (3) and septicaemia of unknown origin (2). There were three postoperative deaths. The positive predictive value for infection of CRP > 145 mg/l on postoperative day 4 was 61%. The negative predictive value of CRP < 145 mg/l on postoperative day 4 for an infective complication was 96%. Conclusion: A CRP > 145 mg/l on day 4 has high specificity and sensitivity for infective complications following elective colorectal resection.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | O'Dwyer, Professor Patrick and Molloy, Mr Richard |
Authors: | MacKay, G. J., Molloy, R.G., and O'Dwyer, P.J. |
College/School: | College of Medical Veterinary and Life Sciences |
Journal Name: | Colorectal Disease |
Publisher: | Wiley-Blackwell Publishing |
ISSN: | 1462-8910 |
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