Quantifying fenbendazole and its metabolites in self-medicating wild red grouse Lagopus lagopus scoticus using an HPLC–MS–MS approach

Adam, A., Webster, L.M.I., Mullen, W., Keller, L.F. and Johnson, P.C.D. (2011) Quantifying fenbendazole and its metabolites in self-medicating wild red grouse Lagopus lagopus scoticus using an HPLC–MS–MS approach. Veterinary Parasitology, 177(3-4), pp. 383-386. (doi: 10.1016/j.vetpar.2010.12.013)

Abstract

On red grouse estates in the UK the nematode parasite Trichostrongylus tenuis is often controlled by application of grit medicated with the anthelmintic fenbendazole (FBZ). To date, assessment of the efficacy has been inhibited by the inability to quantify uptake of FBZ by the birds. We have developed a simple and sensitive HPLC–MS–MS method for detecting and quantifying FBZ and its metabolites from a 300 mg sample of red grouse liver. This method could be used to improve the efficacy of medicated grit treatment by allowing the identification of conditions and application methods that optimize the uptake of FBZ. With the necessary modifications, our method will also be applicable to other wildlife species where self-medication is used for parasite control.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Johnson, Dr Paul
• Authors: Adam, A., Webster, L.M.I., Mullen, W., Keller, L.F., and Johnson, P.C.D.
• Subjects: S Agriculture > SF Animal culture > SF600 Veterinary Medicine
• College/School: College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
• Journal Name: Veterinary Parasitology
• Publisher: Elsevier
• ISSN: 0304-4017
• ISSN (Online): 1873-2550
• Published Online: 21 December 2010
• Copyright Holders: Copyright © 2011 Elsevier
• First Published: First published in Veterinary Parasitology 177(3-4):383-386
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher