Mischak, H. and Schanstra, J.P. (2010) CE-MS in biomarker discovery, validation, and clinical application. Proteomics Clinical Applications, 5(1-2), pp. 9-23. (doi: 10.1002/prca.201000058)
Full text not currently available from Enlighten.
Publisher's URL: http://dx.doi.org/10.1002/prca.201000058
Abstract
CE coupled MS (CE-MS) has become an increasingly employed technology in proteome analysis with focus on the identification of biomarker peptides in clinical proteomics. In this review, we will cover technical aspects of CE-MS coupling and highlight the improvements made in the last few years. We examine CE-MS from an application point of view, and evaluate its merits and vices for biomarker discovery and clinical applications. We discus the principal theoretical and practical obstacles encountered when employing CE-MS (and most other proteomic technologies) for the analysis of body fluids for biomarker discovery. We will present several examples of a successful application of CE-MS for biomarker discovery, implications for disease diagnosis, prognosis, and therapy evaluation, and will discuss current challenges and possible future improvements
Item Type: | Articles |
---|---|
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Mischak, Professor Harald |
Authors: | Mischak, H., and Schanstra, J.P. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
Journal Name: | Proteomics Clinical Applications |
ISSN: | 1862-8346 |
University Staff: Request a correction | Enlighten Editors: Update this record