p53 and its mutants in tumor cell migration and invasion

Muller, P.A.J., Vousden, K. and Norman, J.C. (2011) p53 and its mutants in tumor cell migration and invasion. Journal of Cell Biology, 192(2), pp. 209-218. (doi:10.1083/jcb.201009059)

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Abstract

In about half of all human cancers, the tumor suppressor p53 protein is either lost or mutated, frequently resulting in the expression of a transcriptionally inactive mutant p53 protein. Loss of p53 function is well known to influence cell cycle checkpoint controls and apoptosis. But it is now clear that p53 regulates other key stages of metastatic progression, such as cell migration and invasion. Moreover, recent data suggests that expression of mutant p53 is not the equivalent of p53 loss, and that mutant p53s can acquire new functions to drive cell migration, invasion, and metastasis, in part by interfering with p63 function.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Norman, Professor James and Vousden, Karen and Muller, Dr Patricia
Authors: Muller, P.A.J., Vousden, K., and Norman, J.C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Journal of Cell Biology
ISSN:0021-9525
ISSN (Online):1540-8140

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