Nomogram for the decline in serum antimüllerian hormone: a population study of 9,601 infertility patients

Nelson, S.M. , Messow, M.C. , Wallace, A.M., Fleming, R. and McConnachie, A. (2011) Nomogram for the decline in serum antimüllerian hormone: a population study of 9,601 infertility patients. Fertility and Sterility, 95(2), 736-741.e3. (doi: 10.1016/j.fertnstert.2010.08.022)

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Objective: To define an optimal model for the decline in circulating antimullerian hormone (AMH) with age and develop a validated age-related nomogram. Design: Cohort study with validation of linear, biphasic linear, differential, power, and quadratic equations undertaken in two additional cohorts. Setting: United Kingdom infertility clinics. Patient(s): Training cohort of 4,590 infertile women. Two separate validation cohorts; 4,588 infertile women, and 423 women with confirmed ovulation and normal pelvic ultrasound who have a male partner with severe oligospermia. Intervention(s): Serum AMH measurement. Main Outcome Measure(s): Optimal fit and age-related AMH nomogram. Result(s): The linear model had the largest sum of absolute and squared residuals and provided a less adequate fit than the four nonlinear models. Of these, the R-2 ranged from 19.45% to 19.48% in the training dataset, from 21.30% to 21.36% in the validation dataset, and from 13.29% to 13.75% in the partners of oligospermic males. The parameters of the differential model were difficult to estimate, and the goodness-of-fit of the power model was slightly inferior to the quadratic model. Conclusion(s): Circulating AMH concentrations decline with increasing reproductive age in a manner optimally described by a quadratic equation. This validated age-related AMH nomogram will enable counseling of infertility patients regarding reproductive performance.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Nelson, Professor Scott and Messow, Dr Martina and McConnachie, Professor Alex and Fleming, Professor Richard
Authors: Nelson, S.M., Messow, M.C., Wallace, A.M., Fleming, R., and McConnachie, A.
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre
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College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities
Journal Name:Fertility and Sterility

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