Falaschetti, E., Hingorani, A. D., Jones, A., Charakida, M., Finer, N., Whincup, P., Lawlor, D. A., Davey Smith, G., Sattar, N. and Deanfield, J. E. (2010) Adiposity and cardiovascular risk factors in a large contemporary population of pre-pubertal children. European Heart Journal, 31(24), pp. 3063-3072. (doi: 10.1093/eurheartj/ehq355)
Full text not currently available from Enlighten.
Publisher's URL: http://dx.doi.org/10.1093/eurheartj/ehq355
Abstract
To examine the associations of several markers of adiposity and a wide range of cardiovascular risk factors and biomarkers in pre-pubertal children. Four measures of adiposity,body mass index (BMI), waist circumference, dual-energy X-ray absorptiometry (DXA)-determined fat mass, and leptin concentration, were available in up to 7589 children aged 8.8-11.7 (9.9 mean) years from the Avon Longitudinal Study of Parents and Children (ALSPAC). Thirteen per cent of boys and 18.8% of girls were overweight, and 5.3% of boys and 5% of girls were obese. Body mass index was highly correlated with waist circumference (r = 0.91), DXA fat mass (r = 0.87), and leptin concentration (r = 0.75), and all had similar associations with cardiovascular risk factors. A 1 kg/m(2) greater BMI was associated with 1.4mmHg (95% CI 1.25-1.44) higher systolic blood pressure (BP). In 5002 children, a 1 kg/m(2) greater BMI was associated with a 0.05 mmol/L (95% CI 0.036-0.055) higher non-high-density lipoprotein (HDL) cholesterol and 0.03 mmol/L (95% CI -0.034 to -0.025) lower HDL cholesterol. There were also graded associations with apolipoproteins A1 and B, interleukin-6, and C-reactive protein. Comparing children who were obese with those who were normal weight, the odds ratio for hypertension was 10.7 (95% CI 7.2-15.9) for boys and 13.5 (95% CI 9.4-19.5) for girls. In pre-pubertal UK children, overweight/obesity is common and has broadly similar associations with BP, HDL cholesterol, and non-HDL cholesterol to those observed in adults. Future research should evaluate whether effective interventions to maintain healthy weight in childhood could have important benefits for adult cardiovascular risk.
Item Type: | Articles |
---|---|
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Davey Smith, Professor George and Sattar, Professor Naveed |
Authors: | Falaschetti, E., Hingorani, A. D., Jones, A., Charakida, M., Finer, N., Whincup, P., Lawlor, D. A., Davey Smith, G., Sattar, N., and Deanfield, J. E. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences |
Journal Name: | European Heart Journal |
ISSN: | 0195-668X |
University Staff: Request a correction | Enlighten Editors: Update this record