Petrie, J. R. , Pearson, E. R. and Sutherland, C. (2011) Implications of genome wide association studies for the understanding of type 2 diabetes pathophysiology. Biochemical Pharmacology, 81(4), pp. 471-477. (doi: 10.1016/j.bcp.2010.11.010)
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Publisher's URL: http://dx.doi.org/10.1016/j.bcp.2010.11.010
Abstract
The rapid rise in prevalence of type 2 diabetes mellitus(T2DM)has been driven by changes in environmental factors – primarily increased caloric intake and reduced energy expenditure – resulting in reduced whole body insulin sensitivity(often termed insulin resistance). Insulin resistance has been proposed to be a major driver of progression to T2DM. However, of 38 individual susceptibility loci for T2DM recently identified by genome wide association studies, by far the majority code for proteins involved in b-cell function. In this review, we discuss the possible reasons for the paucity of insulin resistance genes and ask whether the new genetic susceptibility data should focus attention on b-cell targets in the development of therapies for T2DM.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Petrie, Professor John |
| Authors: | Petrie, J. R., Pearson, E. R., and Sutherland, C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Biochemical Pharmacology |
| ISSN: | 0006-2952 |
| Published Online: | 25 November 2010 |
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