The aetiology of upper aerodigestive tract cancers among young adults in Europe: the ARCAGE study

Macfarlane, T. V. et al. (2010) The aetiology of upper aerodigestive tract cancers among young adults in Europe: the ARCAGE study. Cancer Causes and Control, 21(12), pp. 2213-2221. (doi: 10.1007/s10552-010-9641-3)

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<b>Background</b><p></p> The incidence of cancers of the upper aerodigestive tract (UADT) is increasing throughout the world. To date the increases have been proportionally greatest among young people. Several reports have suggested that they often do not have a history of tobacco smoking or heavy alcohol consumption.<p></p> <b>Objective</b><p></p> To determine the contribution of lifestyle factors to the etiology of UADT cancers occurring in those aged less than 50 years.<p></p> <b>Methods</b><p></p> A case–control study was conducted in 10 European countries. Cases were cancers of the oral cavity and pharynx, larynx and esophagus, and hospital or population controls were age and sex matched.<p></p> <b>Results</b><p></p> There were 356 cases younger than 50 years and 419 controls. Risk was strongly related to current smoking [odds ratio (OR) 5.5 95%; confidence interval (CI) (3.3, 9.2)], and risk increased with number of pack-years smoked. Risk was also related to alcohol consumption for both current (OR 1.8; 0.97, 3.3) and past (OR 3.4; 1.6, 7.4) drinkers, and risk increased with number of drink-years. Persons frequently consuming fruits and vegetables were at significantly reduced risk.<p></p> <b>Conclusions</b><p></p> Risk factors already identified as being important for UADT cancers in adults are also important influences on risk in younger adults. The implication of these results is that the public health message in preventing UADT cancers remains the same to young and old alike.<p></p>

Item Type:Articles
Glasgow Author(s) Enlighten ID:Conway, Professor David
Authors: Macfarlane, T. V., Macfarlane, G. J., Oliver, R. J., Benhamou, S., Bouchardy, C., Ahrens, W., Pohlabeln, H., Lagiou, P., Lagiou, A., Castellsague, X., Agudo, A., Merletti, F., Richiardi, L., Kjaerheim, K., Slamova, A., Schejbalova, M., Canova, C., Simonato, L., Talamini, R., Barzan, L., Conway, D. I., McKinney, P. A., Znaor, A., Lowry, R. J., Thomson, P., Healy, C. M., McCartan, B. E., Marron, M., Hashibe, M., and Brennan, P.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:Cancer Causes and Control
Publisher:Springer Science+Business Media B.V
ISSN (Online):1573-7225
Published Online:11 September 2010
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