Bryant, N.J. and Gould, G.W. (2011) SNARE proteins underpin insulin-regulated GLUT4 traffic. Traffic, 12(6), pp. 657-664. (doi: 10.1111/j.1600-0854.2011.01163.x)
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Publisher's URL: http://dx.doi.org/10.1111/j.1600-0854.2011.01163.x
Abstract
Delivery of the glucose transporter, GLUT4 from an intracellular location to the cell surface in response to insulin represents a specialised form of membrane traffic, known to be impaired in the disease states of insulin-resistance and Type-2 diabetes. Like all membrane trafficking events, this translocation of GLUT4 requires members of the SNARE family of proteins. Here we discuss two SNARE complexes that have been implicated in insulin-regulated GLUT4 traffic: One regulating the final delivery of GLUT4 to the cell surface in response to insulin; the other controlling GLUT4's intracellular trafficking.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Gould, Professor Gwyn and Bryant, Dr Nia |
Authors: | Bryant, N.J., and Gould, G.W. |
College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
Journal Name: | Traffic |
ISSN: | 1398-9219 |
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