Horn, D. and McCulloch, R. (2010) Molecular mechanisms underlying the control of antigenic variation in African trypanosomes. Current Opinion in Microbiology, 13(6), pp. 700-705. (doi: 10.1016/j.mib.2010.08.009)
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Publisher's URL: http://dx.doi.org/10.1016/j.mib.2010.08.009
Abstract
African trypanosomes escape the host adaptive immune response by switching their dense protective coat of Variant Surface Glycoprotein (VSG). Each cell expresses only one VSG gene at a time from a telomeric expression site (ES). The [`]pre-genomic' era saw the identification of the range of pathways involving VSG recombination in the context of mono-telomeric VSG transcription. A prominent feature of the early post-genomic era is the description of the molecular machineries involved in these processes. We describe the factors and sequences recently linked to mutually exclusive transcription and VSG recombination, and how these act in the control of the key virulence mechanism of antigenic variation
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | McCulloch, Professor Richard |
| Authors: | Horn, D., and McCulloch, R. |
| Subjects: | Q Science > QR Microbiology |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Current Opinion in Microbiology |
| Publisher: | Elsevier |
| ISSN: | 1369-5274 |
| ISSN (Online): | 1879-0364 |
| Published Online: | 29 September 2010 |
| Copyright Holders: | Copyright © 2010 Elsevier |
| First Published: | First published in Current Opinion in Microbiology 2010 13(6): 700-705 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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