Longman, D., Arrisi, P., Johnstone, I.L. and Cáceres, J.F. (2008) Nonsense‐mediated mRNA decay in Caenorhabditis elegans. In: RNA Turnover in Eukaryotes: Analysis of Specialized and Quality Control RNA Decay Pathways. Series: Methods in Enzymology, 449. Academic Press, p. 149. ISBN 9780123745842 (doi: 10.1016/S0076-6879(08)02407-5)
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Publisher's URL: http://dx.doi.org/10.1016/S0076-6879(08)02407-5
Abstract
The nonsense[hyphen (true graphic)]mediated mRNA decay (NMD) pathway is a surveillance mechanism that targets the degradation of mRNAs harboring premature termination codons (PTCs). Two key aspects of NMD are the definition of a PTC codon and the identification of the molecular machinery dedicated to this mechanism. This chapter describes the development of transgenic reporters as well as the use of genome[hyphen (true graphic)]wide RNAi and genetic screens to identify novel components of the NMD pathway in the nematode Caenorhabditis elegans
| Item Type: | Book Sections |
|---|---|
| Status: | Published |
| Glasgow Author(s) Enlighten ID: | Johnstone, Professor Iain |
| Authors: | Longman, D., Arrisi, P., Johnstone, I.L., and Cáceres, J.F. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Life Sciences College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
| Publisher: | Academic Press |
| ISSN: | 00766879 |
| ISBN: | 9780123745842 |
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