Monocyte chemoattractant protein-1: A dichotomous role in cardiac remodeling following acute myocardial infarction in man?

Weir, R.A.P., Murphy, C.A., Petrie, C.J., Martin, T.N., Clements, S., Steedman, T., Wagner, G.S., McMurray, J.J.V. and Dargie, H.J. (2010) Monocyte chemoattractant protein-1: A dichotomous role in cardiac remodeling following acute myocardial infarction in man? Cytokine, 50(2), pp. 158-162. (doi: 10.1016/j.cyto.2010.02.020)

Abstract

Introduction: Monocyte chemoattractant protein-1 (MCP-1) is elevated after acute myocardial infarction (AMI), and potentiates left ventricular (LV) remodeling in murine models of AMI. We examined the relationships between serum MCP-1, change in LV function and biomarkers related to remodeling in a cohort of AMI patients. Methods: Serum MCP-1 concentrations were measured in 100 patients (age 58.9 ± 12.0 years, 77% male) admitted with AMI and LV dysfunction, at baseline (mean 46 h), 12 and 24 weeks; cardiac magnetic resonance imaging and measurement of matrix metalloproteinase-2 (MMP-2), MMP-3 and MMP-9 occurred at each time-point. Results: MCP-1 increased significantly from 697 [483, 997] pg/mL at baseline to 878 [678, 1130] pg/mL at 24 weeks (p > 0.001). MMP-3 concentration increased while MMP-9 decreased significantly over time; MMP-2 concentration did not change significantly. Baseline MCP-1 correlated with change in (Δ) LV end-systolic volume index (ΔLVESVI; r = -0.48, p = 0.01) and with ΔLV ejection fraction (ΔLVEF; r = 0.50, p = 0.02). However, ΔMCP-1 correlated positively with ΔLVESVI (r = 0.40, p = 0.006) and negatively with ΔLVEF (r = −0.36, p = 0.004). MCP-1 had no relationship with any MMP. Conclusions: MCP-1 may have a dichotomous role following AMI, aiding early infarct healing but potentiating later remodeling, which merits further study before any therapeutic trials of MCP-1 modulation in humans.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Dargie, Professor Henry and McMurray, Professor John and Hopkins, Mrs Tracey
• Authors: Weir, R.A.P., Murphy, C.A., Petrie, C.J., Martin, T.N., Clements, S., Steedman, T., Wagner, G.S., McMurray, J.J.V., and Dargie, H.J.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences
• Journal Name: Cytokine
• ISSN: 1043-4666