Pol II and its associated epigenetic marks are present at Pol III–transcribed noncoding RNA genes

Barski, A., Chepelev, I., Liko, D., Cuddapah, S., Fleming, A., Birch, J., Cui, K., White, R.J. and Zhao, K. (2010) Pol II and its associated epigenetic marks are present at Pol III–transcribed noncoding RNA genes. Nature Structural and Molecular Biology, 17(5), pp. 629-634. (doi: 10.1038/nsmb.1806)

Abstract

Epigenetic control is an important aspect of gene regulation. Despite detailed understanding of protein-coding gene expression, the transcription of noncoding RNA genes by RNA polymerase III (Pol III) is less well characterized. Here we profile the epigenetic features of Pol III target genes throughout the human genome. This reveals that the chromatin landscape of Pol III–transcribed genes resembles that of Pol II templates in many ways, although there are also clear differences. Our analysis also uncovered an entirely unexpected phenomenon: namely, that Pol II is present at the majority of genomic loci that are bound by Pol III.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Birch, Dr Joanna and Liko, Dr Dritan and Fleming, Dr Alastair and White, Prof Robert
• Authors: Barski, A., Chepelev, I., Liko, D., Cuddapah, S., Fleming, A., Birch, J., Cui, K., White, R.J., and Zhao, K.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Nature Structural and Molecular Biology
• ISSN: 1545-9993