Wittek, T., Tischer, K., Korner, I., Sattler, T., Constable, P.D. and Furll, M. (2008) Effect of preoperative erythromycin or dexamethasone/vitamin C on postoperative abomasal emptying rate in dairy cows undergoing surgical correction of abomasal volvulus. Veterinary Surgery, 37(6), pp. 537-544. (doi: 10.1111/j.1532-950X.2008.00401.x)
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Abstract
<p> <b>Objective</b> — To determine the effects of preoperative erythromycin or combined dexamethasone/vitamin C treatment on postoperative abomasal emptying rate in cows undergoing surgical correction of abomasal volvulus (AV). </p> <p> <b>Study Design</b> — Prospective, controlled, clinical study using a convenience sample. </p> <p> <b>Animals</b> — Lactating Holstein–Friesian cows (n=45) with AV were alternately assigned to 3 groups (n=15): group C: untreated (control); group E: erythromycin (10 mg/kg intramuscularly [IM]); group D: dexamethasone (0.02 mg/kg intravenously [IV]) and vitamin C (10 mg<kg IV). </p> <p> <b>Methods</b> — Drugs were administered 1 hour before surgical correction of AV. d-xylose solution (50%, 0.5 g/kg body weight) was injected into the abomasal lumen during surgery. Jugular venous blood samples for determination of serum d-xylose concentration were periodically obtained. Time to maximal serum d-xylose concentration (Tmax-model) was pharmacokinetically determined. </p> <p> <b>Results</b> — Abomasal emptying rate was significantly (P<0.05) faster in group E (Tmax-model=182±69 min; mean±SD) than in group C cows (Tmax-model=237±64 min). Abomasal emptying rate was similar in group D (Tmax-model=196±47 min) and group C. Both treatments improved postoperative milk yield within 1 day after surgery. </p> <p> <b>Conclusion</b> — Preoperative injection of erythromycin (10 mg/kg IM) is an effective method for ameliorating postoperative abomasal hypomotility in cows with AV. </p> <p> <b>Clinical Relevance</b> — Parenteral erythromycin can be recommended for preoperative treatment of cows with AV. </p>
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Wittek, Dr Thomas |
| Authors: | Wittek, T., Tischer, K., Korner, I., Sattler, T., Constable, P.D., and Furll, M. |
| Subjects: | S Agriculture > SF Animal culture > SF600 Veterinary Medicine |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Veterinary Surgery |
| ISSN: | 0161-3499 |
| ISSN (Online): | 1532-950X |
| Published Online: | 31 July 2008 |
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