Solution structure of the leader sequence of the patellamide precursor peptide, PatE1-34

Houssen, W.E., Wright, S.H., Kalverda, A.P., Thompson, G.S., Kelly, S.M. and Jaspars, M. (2010) Solution structure of the leader sequence of the patellamide precursor peptide, PatE1-34. ChemBioChem, 11(13), pp. 1867-1873. (doi:10.1002/cbic.201000305)

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Publisher's URL: http://dx.doi.org/10.1002/cbic.201000305

Abstract

The solution structure of the leader sequence of the patellamide precursor peptide was analysed by using CD and determined with NOE-restrained molecular dynamics calculations. This leader sequence is highly conserved in the precursor peptides of some other cyanobactins harbouring heterocycles, and is assumed to play a role in targeting the precursor peptide to the post-translational machinery. The sequence was observed to form an a-helix spanning residues 13-28 with a hydrophobic surface on one side of the helix. This hydrophobic surface is proposed to be the site of the initial binding with modifying enzymes

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kelly, Dr Sharon
Authors: Houssen, W.E., Wright, S.H., Kalverda, A.P., Thompson, G.S., Kelly, S.M., and Jaspars, M.
College/School:College of Medical Veterinary and Life Sciences
Journal Name:ChemBioChem
ISSN:1439-4227

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