Genetic exchange in Trypanosoma brucei: evidence for mating prior to metacyclic stage development

Tait, A., MacLeod, A. , Tweedie, A., Masiga, D. and Turner, C.M.R. (2005) Genetic exchange in Trypanosoma brucei: evidence for mating prior to metacyclic stage development. Molecular and Biochemical Parasitology, 151(1), pp. 133-136. (doi: 10.1016/j.molbiopara.2006.10.009)



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It is well established that genetic exchange occurs between Trypanosoma brucei parasites when two stocks are used to infect tsetse flies under laboratory conditions and a number of such crosses have been undertaken. Both cross and self-fertilisation can take place and, with the products of mating being the equivalent of F1 progeny in a Mendelian system and. Recently, analysis of a large collection of independent progeny using a series of polymorphic micro and minisatellite markers, has formally demonstrated that the allelic segregation at loci on each of the 11-megabase chromosomes conforms to ratios predicted for a classical diploid genetic system involving meiosis as well as independent assortment of markers on different chromosomes. Further extensive analysis of these F1 progeny, using a large panel of micro and minisatellite markers, has led to the construction of a genetic map of one parasite stock A. MacLeod, A. Tweedie and S. McLellan et al., The genetic map of Trypanosoma brucei, Nucleic Acids Res 33 (2005), pp. 6688–6693. Full Text via CrossRef | View Record in Scopus | Cited By in Scopus (10).

Item Type:Articles
Keywords:Trypanosoma brucei; Genetic exchange; Life cycle stage
Glasgow Author(s) Enlighten ID:MacLeod, Professor Annette and Tait, Professor Andy
Authors: Tait, A., MacLeod, A., Tweedie, A., Masiga, D., and Turner, C.M.R.
Subjects:Q Science > QR Microbiology > QR355 Virology
College/School:College of Medical Veterinary and Life Sciences
Journal Name:Molecular and Biochemical Parasitology
Publisher:Elsevier BV
ISSN (Online):1872-9428
Copyright Holders:Copyright © 2006 Elsevier
First Published:First published in Molecular and Biochemical Parasitology 151(1):133-136
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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