Sub-cortical and brainstem sites associated with chemo-stimulated increases in ventilation in humans

McKay, L.C. , Critchley, H.D., Murphy, K., Frackowiak, R.S.J. and Corfield, D.R. (2010) Sub-cortical and brainstem sites associated with chemo-stimulated increases in ventilation in humans. NeuroImage, 49(3), pp. 2526-2535. (doi:10.1016/j.neuroimage.2009.11.007) (PMID:19913627)

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Abstract

We investigated the neural basis for spontaneous chemo-stimulated increases in ventilation in awake, healthy humans. Blood oxygen level dependent (BOLD) functional MRI was performed in nine healthy subjects using T2weighted echo planar imaging. Brain volumes (52 transverse slices, cortex to high spinal cord) were acquired every 3.9 s. The 30 min paradigm consisted of six, 5-min cycles, each cycle comprising 45 s of hypoxic-isocapnia, 45 s of isooxic-hypercapnia and 45 s of hypoxic-hypercapnia, with 55 s of non-stimulatory hyperoxic-isocapnia (control) separating each stimulus period. Ventilation was significantly (p < 0.001) increased during hypoxic-isocapnia, isooxic-hypercapnia and hypoxic-hypercapnia (17.0, 13.8, 24.9 L/min respectively) vs. control (8.4 L/min) and was associated with significant (p < 0.05, corrected for multiple comparisons) signal increases within a bilateral network that included the basal ganglia, thalamus, red nucleus, cerebellum, parietal cortex, cingulate and superior mid pons. The neuroanatomical structures identified provide evidence for the spontaneous control of breathing to be mediated by higher brain centres, as well as respiratory nuclei in the brainstem.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McKay, Dr Leanne
Authors: McKay, L.C., Critchley, H.D., Murphy, K., Frackowiak, R.S.J., and Corfield, D.R.
Subjects:R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:NeuroImage
Publisher:Elsevier Inc.
ISSN:1053-8119
ISSN (Online):1095-9572
Published Online:11 November 2009
Copyright Holders:Copyright © 2010 Elsevier
First Published:First published in NeuroImage 49(3):2526-2535
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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