Payne, R.J., Riboldi-Tunnicliffe, A., Kerbarh, O., Abell, A.D., Lapthorn, A.J. and Abell, C. (2007) Design, synthesis, and structural studies on potent biaryl inhibitors of type II dehydroquinases. ChemMedChem, 2(7), pp. 1010-1013. (doi: 10.1002/cmdc.200700062)
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Abstract
Filling the pocket: Biaryl inhibitors of type II dehydroquinase are described, designed to bind to both the active site and a subsidiary pocket. Compounds exhibited nanomolar inhibition of the enzyme, which is rationalised by molecular docking and protein crystallographic studies.
| Item Type: | Articles (Other) |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Lapthorn, Dr Adrian and Riboldi-Tunnicliffe, Dr Alan |
| Authors: | Payne, R.J., Riboldi-Tunnicliffe, A., Kerbarh, O., Abell, A.D., Lapthorn, A.J., and Abell, C. |
| Subjects: | Q Science > QD Chemistry |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | ChemMedChem |
| ISSN: | 1860-7187 |
| Published Online: | 08 May 2007 |
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