Tran, A.T., Cergol, K.M., West, N.P., Randall, E.J., Britton, W.J., Bokhari, S.A.I., Ibrahim, M., Lapthorn, A.J. and Payne, R.J. (2011) Synthesis and evaluation of potent ene-yne inhibitors of type II dehydroquinases as tuberculosis drug leads. ChemMedChem, 6(2), pp. 262-265. (doi: 10.1002/cmdc.201000399)
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Publisher's URL: http://dx.doi.org/10.1002/cmdc.201000399
Abstract
E-9: You sunk my battleship! Potent ene–yne-based inhibitors of type II dehydroquinase are described. The majority of the compounds exhibited nanomolar inhibition of the <i>Streptomyces coelicolor</i>, <i>Helicobacter pylori</i> and <i>Mycobacterium tuberculosis</i> type II dehydroquinases. The inhibitors also possessed moderate activity against the growth of <i>M. tuberculosis</i> in vitro.
| Item Type: | Articles |
|---|---|
| Keywords: | Antibiotics, dehydroquinases, medicinal chemistry, Mycobacterium tuberculosis, shikimate pathway |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Lapthorn, Dr Adrian |
| Authors: | Tran, A.T., Cergol, K.M., West, N.P., Randall, E.J., Britton, W.J., Bokhari, S.A.I., Ibrahim, M., Lapthorn, A.J., and Payne, R.J. |
| Subjects: | Q Science > QD Chemistry |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | ChemMedChem |
| ISSN: | 1860-7179 |
| ISSN (Online): | 1860-7187 |
| Published Online: | 04 November 2010 |
| Related URLs: |
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