T cell-mediated autoimmune disease due to low-affinity crossreactivity to common microbial peptides

Harkiolaki, M. et al. (2009) T cell-mediated autoimmune disease due to low-affinity crossreactivity to common microbial peptides. Immunity, 30(3), pp. 348-357. (doi: 10.1016/j.immuni.2009.01.009)

Abstract

Environmental factors account for 75% of the risk of developing multiple sclerosis (MS). Numerous infections have been suspected as environmental disease triggers, but none of them has consistently been incriminated, and it is unclear how so many different infections may play a role. We show that a microbial peptide, common to several major classes of bacteria, can induce MS-like disease in humanized mice by crossreacting with a T cell receptor (TCR) that also recognizes a peptide from myelin basic protein, a candidate MS autoantigen. Structural analysis demonstrates this crossreactivity is due to structural mimicry of a binding hotspot shared by self and microbial antigens, rather than to degenerate TCR recognition. Biophysical studies reveal that the autoreactive TCR binding affinity is markedly lower for the microbial (mimicry) peptide than for the autoantigenic peptide. Thus, these data suggest a possible explanation for the difficulty in incriminating individual infections in the development of MS.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Kranc, Professor Kamil
• Authors: Harkiolaki, M., Holmes, S.L., Svendsen, P., Gregersen, J.W., Jensen, L.T., McMahon, R., Friese, M.A., van Boxel, G., Etzensperger, R., Tzartos, J.S., Kranc, K., Sainsbury, S., Harlos, K., Mellins, E.D., Palace, J., Esiri, M.M., van der Merwe, P.A., Jones, E.Y., and Fugger, L.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Immunity
• ISSN: 1074-7613
• Published Online: 19 March 2009