Dobbin, E., Corrigan, P.M., Walsh, C.P., Welham, M.J., Freeburn, R.W. and Wheadon, H. (2008) Tel/PDGFRβ inhibits self-renewal and directs myelomonocytic differentiation of ES cells. Leukemia Research, 32(10), pp. 1554-1564. (doi: 10.1016/j.leukres.2008.02.007)
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Abstract
The leukemic oncogene Tel/PDGFRβ, was inducibly expressed in embryonic stem (ES) cells and the phenotypic and molecular changes occurring during hematopoietic differentiation investigated. Expression of Tel/PDGFRβ resulted in an inability of ES cells to self-renew and caused a significant increase in myelopoiesis with a corresponding decrease in erythropoiesis. Analysis of gene expression patterns indicated a dramatic alteration in the levels of genes associated with self-renewal and differentiation, especially myelomonocytic genes in Tel/PDGFRβ-expressing cells. This study indicates Tel/PDGFRβ drives myelopoiesis by altering expression of genes involved in hematopoiesis and demonstrates the potential of this stem cell system to study oncogene-induced pathogenesis.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Wheadon, Professor Helen |
| Authors: | Dobbin, E., Corrigan, P.M., Walsh, C.P., Welham, M.J., Freeburn, R.W., and Wheadon, H. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Leukemia Research |
| ISSN: | 01452126 |
| Published Online: | 19 March 2008 |
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