Cell cycle regulated gene expression in yeasts

McInerny, C.J. (2011) Cell cycle regulated gene expression in yeasts. Advances in Genetics, 73, pp. 51-85. (doi: 10.1016/B978-0-12-380860-8.00002-1)

Abstract

The regulation of gene expression through the mitotic cell cycle, so that genes are transcribed at particular cell cycle times, is widespread among eukaryotes. In some cases, it appears to be important for control mechanisms, as deregulated expression results in uncontrolled cell divisions, which can cause cell death, disease, and malignancy. In this review, I describe the current understanding of such regulated gene expression in two established simple eukaryotic model organisms, the budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe. In these two yeasts, the global pattern of cell cycle gene expression has been well described, and most of the transcription factors that control the various waves of gene expression, and how they are in turn themselves regulated, have been characterized. As related mechanisms occur in all other eukaryotes, including humans, yeasts offer an excellent paradigm to understand this important molecular process.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: McInerny, Dr Chris
• Authors: McInerny, C.J.
• College/School: College of Medical Veterinary and Life Sciences > School of Life Sciences; College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
• Journal Name: Advances in Genetics
• Journal Abbr.: Adv. Genet.
• ISSN: 0065-2660
• ISBN: 978-0-12-374621-4
• Published Online: 08 February 2011