A good catch: packaging the virus genome

Rixon, F.J. (2008) A good catch: packaging the virus genome. Cell Host and Microbe, 3(3), pp. 120-122. (doi: 10.1016/j.chom.2008.02.009) (PMID:18329609)

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In tailed bacteriophages and herpesviruses, double-stranded DNA is packaged into a pre-existing protein shell, through a dedicated channel known as the portal. In a recent issue of Molecular Cell, Zheng et al. determined the structure of the bacteriophage P22 portal complex in pre- and postpackaging conformations, identifying structural changes that serve to retain the genome within the virus particle and prime it for injection into a new host.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Rixon, Dr Frazer
Authors: Rixon, F.J.
Subjects:Q Science > QH Natural history > QH426 Genetics
College/School:College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Cell Host and Microbe
Publisher:Cell Press
ISSN (Online):1934-6069

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
656531Structural studies on human virusesFrazer RixonMedical Research Council (MRC)MC_UU_12014/6MVLS III - CENTRE FOR VIRUS RESEARCH