Impact of peroxisome proliferator-activated receptors γ and δ on adiposity in toddlers and preschoolers in the GENESIS study

Lagou, V. et al. (2008) Impact of peroxisome proliferator-activated receptors γ and δ on adiposity in toddlers and preschoolers in the GENESIS study. Obesity, 16(4), pp. 913-918. (doi: 10.1038/oby.2008.1)

Abstract

Peroxisome proliferator-activated receptor γ (PPAR γ) and peroxisome proliferator-activated receptor δ (PPAR δ) are promising candidate genes for obesity. Associations between adiposity-related phenotypes and genetic variation in PPAR γ (Pro12Ala and C1431T), as well as PPAR δ (T+294C) were assessed in 2,102 Greek children aged 1-6 years, as part of a large-scale epidemiological study (Growth, Exercise and Nutrition Epidemiological Study In preSchoolers). In girls aged 3-4 years, the Ala12 allele was associated with higher mid-upper arm (P = 0.010) and hip (P = 0.005) circumferences, as well as subscapular (P = 0.008) and total skinfolds (P = 0.011) that explained 2.0, 3.7, 2.1, and 1.9% of the phenotypic variance, respectively, while the T1431 allele was associated with higher mean values for waist circumference (P = 0.018) and suprailiac skinfold (P = 0.017), genotype accounting for 1.6% of the variance in both phenotypes. No significant effects of PPAR δ T+294C polymorphism or the interaction of the PPAR δ and PPAR γ variants on adiposity-related phenotypes were observed in any age group or gender. Haplotype-based analysis including both PPAR γ polymorphisms revealed that in girls aged 3-4 years, the Ala-T haplotype was associated with higher waist (P = 0.014) and hip (P = 0.007) circumferences compared to the common Pro-C haplotype. The PPAR γ Pro12Ala and C1431T polymorphisms are associated with increased adiposity during early childhood in a gender- and age-specific manner and independently of the PPAR δ T+294C polymorphism.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Pitsiladis, Dr Yannis
• Authors: Lagou, V., Scott, R.A., Manios, Y., Chen, T.L.J., Wang, G., Grammatikaki, E., Kortsalioudaki, C., Liarigkovinos, T., Moschonis, G., Roma-Giannikou, E., and Pitsiladis, Y.P.
• Subjects: R Medicine > RC Internal medicine
• College/School: College of Medical Veterinary and Life Sciences; College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Obesity
• ISSN: 1930-7381