Kemi, O.J., Ceci, M., Condorelli, G., Smith, G.L. and Wisloff, U. (2008) Myocardial sarcoplasmic reticulurn Ca2+ ATPase function is increased by aerobic interval training. European Journal of Cardiovascular Prevention and Rehabilitation, 15(2), pp. 145-148. (doi: 10.1097/HJR.0b013e3282efd4e0)
Full text not currently available from Enlighten.
Publisher's URL: http://dx.doi.org/10.1097/HJR.0b013e3282efd4e0
Abstract
Objective Reduced activity of the sarcoplasmic reticulum Ca2+ ATPase-2a (SERCA-2a) contributes to myocardial dysfunction. Exercise training improves myocardial Ca2+-handling, but SERCA-2a function is uncertain. We assessed SERCA-2a activity after exercise training. Methods SERCA-2a function was assessed by sarcoplasmic reticulum Ca2+ uptake in cardiornyocytes with other Ca2+ uptake mechanisms blocked, in mice after aerobic interval training versus sedentary controls. Results We established protocols to assess SERCA-2a function, and show that aerobic interval training increases the maximal rate of Ca2+ uptake by 30%. This is at least partly explained by reduced phospholamban-to-SERCA-2a ratio. Conclusion Aerobic interval training improves myocardial SERCA-2a performance, explaining at least partly why myocardial Ca2+-handling improves after exercise training.
Item Type: | Articles |
---|---|
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Smith, Professor Godfrey and Kemi, Dr Ole |
Authors: | Kemi, O.J., Ceci, M., Condorelli, G., Smith, G.L., and Wisloff, U. |
Subjects: | Q Science > QP Physiology |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences |
Journal Name: | European Journal of Cardiovascular Prevention and Rehabilitation |
ISSN: | 1741-8267 |
University Staff: Request a correction | Enlighten Editors: Update this record