Neuronal circuitry for pain processing in the dorsal horn

Todd, A.J. (2010) Neuronal circuitry for pain processing in the dorsal horn. Nature Reviews Neuroscience, 11(12), pp. 823-836. (doi: 10.1038/nrn2947)

[img] Text



Neurons in the spinal dorsal horn process sensory information, which is then transmitted to several brain regions, including those responsible for pain perception. The dorsal horn provides numerous potential targets for the development of novel analgesics and is thought to undergo changes that contribute to the exaggerated pain felt after nerve injury and inflammation. Despite its obvious importance, we still know little about the neuronal circuits that process sensory information, mainly because of the heterogeneity of the various neuronal components that make up these circuits. Recent studies have begun to shed light on the neuronal organization and circuitry of this complex region.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Todd, Professor Andrew
Authors: Todd, A.J.
Subjects:R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
College/School:College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:Nature Reviews Neuroscience
Publisher:Nature Publishing Group
ISSN (Online):1471-0048
Published Online:11 November 2010
Copyright Holders:Copyright © 2010 Macmillan Publishers
First Published:First published in Nature Reviews Neuroscience 11(12):823-836
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

University Staff: Request a correction | Enlighten Editors: Update this record

Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
403051AMPA receptors in the spinal dorsal horn - synaptic distribution and plasticity in pain statesAndrew ToddWellcome Trust (WELLCOME)076976/Z/05/ZInstitute of Neuroscience and Psychology