Ventilatory control during intermittent high-intensity exercise in humans

Cathcart, A.J., Turner, A.P., Butterworth, C., Parker, M., Wilson, J. and Ward, S.A. (2008) Ventilatory control during intermittent high-intensity exercise in humans. In: Integration in Respiratory Control: from Genes to Systems. Springer: New York, pp. 203-208. ISBN 9780387736921 (doi: 10.1007/978-0-387-73693-8)

Abstract

Intermittent supra-maximal cycling of varying work: recovery durations was used to explore the kinetics of respiratory compensation for the metabolic acidosis of high-intensity exercise ( gt lactate threshold, theta(L)). For a 10:20s duty-cycle, blood [lactate] ([L-]) was not increased, and there was no evidence of respiratory compensation (RC); Le, no increase in the ventilation (V-E)-CO2 Output (V-CO2) slope, nor fall in end-tidal PCO2 (PETCO2). For longer duty-cycles, [L-] was elevated, stabilizing (30 s:60 s exercise) or rising progressively (60 s: 120 s, 90 s: 180 s exercise). In addition, V-CO2 and VE now oscillated with WR, with evidence of delayed RC (progressive increase in VE - V-CO2 slope; decrease in PETCO2) being more marked with longer duty-cycles. These results, which extend earlier findings with supra- theta(L) step and ramp exercise, are not consistent with an appreciable contribution to RC from zero-order central command or peripheral neurogenesis. The reasons for the slow RC kinetics are unclear, but may reflect in part the H+-signal transduction properties of carotid chemoreceptors

• Item Type: Book Sections
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Cathcart, Dr Andrew and Wilson, Mr John
• Authors: Cathcart, A.J., Turner, A.P., Butterworth, C., Parker, M., Wilson, J., and Ward, S.A.
• Subjects: R Medicine > RB Pathology
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Publisher: Springer
• ISSN: 0065-2598
• ISBN: 9780387736921