Al-Dhaheri, R.S. and Douglas, L.J. (2008) Absence of amphotericin B-tolerant persister cells in biofilms of some Candida species. Antimicrobial Agents and Chemotherapy, 52(5), pp. 1884-1887. (doi: 10.1128/AAC.01473-07)
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Publisher's URL: http://dx.doi.org/10.1128/AAC.01473-07
Abstract
Biofilms and planktonic cells of five Candida species were surveyed for the presence of persister (drug-tolerant) cell populations after exposure to amphotericin B. None of the planktonic cultures (exponential- or stationary-phase) contained persister cells. However, persisters were found in biofilms of one of two strains of C. albicans tested, and in biofilms of C. krusei and C. parapsilosis, but not in biofilms of C. glabrata or C. tropicalis. These results suggest that persister cells cannot solely account for drug resistance in Candida biofilms
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Douglas, Dr Lisbeth |
| Authors: | Al-Dhaheri, R.S., and Douglas, L.J. |
| Subjects: | Q Science > QR Microbiology |
| College/School: | College of Medical Veterinary and Life Sciences |
| Journal Name: | Antimicrobial Agents and Chemotherapy |
| Journal Abbr.: | Antimicrob Agents Chemother |
| Publisher: | American Society for Microbiology |
| ISSN: | 0066-4804 |
| ISSN (Online): | 1098-6596 |
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