Animal models in the study of exercise-induced cardiac hypertrophy

Wang, Y., Wisloff, U. and Kemi, O.J. (2010) Animal models in the study of exercise-induced cardiac hypertrophy. Physiological Research, 59(5), pp. 633-644.

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Exercise training-induced cardiac hypertrophy occurs following a program of aerobic endurance exercise training and it is considered as a physiologically beneficial adaptation. To investigate the underlying biology of physiological hypertrophy, we rely on robust experimental models of exercise training in laboratory animals that mimic the training response in humans. A number of experimental strategies have been established, such as treadmill and voluntary wheel running and swim training models that all associate with cardiac growth. These approaches have been applied to numerous animal models with various backgrounds. However, important differences exist between these experimental approaches, which may affect the interpretation of the results. Here, we review the various approaches that have been used to experimentally study exercise training-induced cardiac hypertrophy; including the advantages and disadvantages of the various models.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Kemi, Dr Ole
Authors: Wang, Y., Wisloff, U., and Kemi, O.J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences
Journal Name:Physiological Research
Published Online:20 April 2010

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