A DNA Nanostructure for the Functional Assembly of Chemical Groups with Tunable Stoichiometry and Defined Nanoscale Geometry

Mitchell, N., Schlapak, R., Kastner, M., Armitage, D., Chrzanowski, W., Riener, J., Hinterdorfer, P., Ebner, A. and Howorka, S. (2009) A DNA Nanostructure for the Functional Assembly of Chemical Groups with Tunable Stoichiometry and Defined Nanoscale Geometry. Angewandte Chemie (International Edition), 48(3), pp. 525-527. (doi: 10.1002/anie.200804264)

Abstract

Many legs make light work: Tetrahedra are constructed with edges of double-stranded DNA and vertices tagged with biotin or disulfide units (see picture). They can act as supramolecular scaffolds to combine different chemical groups at defined nanoscale distances and with tunable stoichiometries. The disulfide groups bind to gold surfaces with high affinity, which leaves the biotin unit poised to capture streptavidin

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Chrzanowski, Dr Wojciech
• Authors: Mitchell, N., Schlapak, R., Kastner, M., Armitage, D., Chrzanowski, W., Riener, J., Hinterdorfer, P., Ebner, A., and Howorka, S.
• College/School: College of Science and Engineering > School of Engineering > Systems Power and Energy
• Journal Name: Angewandte Chemie (International Edition)
• Journal Abbr.: Angew Chem Int Ed Engl
• Publisher: Wiley - V C H Verlag GmbH & Co. KGaA
• ISSN: 1433-7851
• ISSN (Online): 1521-3773