Genome wide analysis of inbred mouse lines identifies a locus containing Ppar-γ as contributing to enhanced malaria surviva

Bopp, S.E.R. et al. (2010) Genome wide analysis of inbred mouse lines identifies a locus containing Ppar-γ as contributing to enhanced malaria surviva. PLoS ONE, 5(5), e10903. (doi: 10.1371/journal.pone.0010903)

Abstract

The genetic background of a patient determines in part if a person develops a mild form of malaria and recovers, or develops a severe form and dies. We have used a mouse model to detect genes involved in the resistance or susceptibility to Plasmodium berghei malaria infection. To this end we first characterized 32 different mouse strains infected with P. berghei and identified survival as the best trait to discriminate between the strains. We found a locus on chromosome 6 by linking the survival phenotypes of the mouse strains to their genetic variations using genome wide analyses such as haplotype associated mapping and the efficient mixed-model for association. This new locus involved in malaria resistance contains only two genes and confirms the importance of Ppar-γ in malaria infection.

• Item Type: Articles
• Additional Information: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Waters, Professor Andy
• Authors: Bopp, S.E.R., Ramachandran, V., Henson, K., Luzader, A., Lindstrom, M., Spooner, M., Steffy, B.M., Suzuki, O., Waters, A.P., Zhou, Y., Wiltshire, T., and Winzeler, E.A.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: PLoS ONE
• Publisher: Public Library of Science
• ISSN: 1932-6203
• ISSN (Online): 1932-6203
• Published Online: 01 January 2010
• Copyright Holders: © 2010 Bopp et al.
• First Published: First published in PLoS ONE 2010 5(5): e10903
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher