Upstream-binding factor is sequestered into herpes simplex virus type 1 replication compartments

Stow, N. D., Evans, V. C. and Matthews, D. A. (2009) Upstream-binding factor is sequestered into herpes simplex virus type 1 replication compartments. Journal of General Virology, 90(1), pp. 69-73. (doi: 10.1099/vir.0.006353-0) (PMID:19088274) (PMCID:PMC2885023)

Abstract

Previous reports have shown that adenovirus recruits nucleolar protein upstream-binding factor (UBF) into adenovirus DNA replication centres. Here, we report that despite having a different mode of viral DNA replication, herpes simplex virus type 1 (HSV-1) also recruits UBF into viral DNA replication centres. Moreover, as with adenovirus, enhanced green fluorescent protein-tagged fusion proteins of UBF inhibit viral DNA replication. We propose that UBF is recruited to the replication compartments to aid replication of HSV-1 DNA. In addition, this is a further example of the role of nucleolar components in viral life cycles

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Stow, Dr Nigel
• Authors: Stow, N. D., Evans, V. C., and Matthews, D. A.
• College/School: College of Medical Veterinary and Life Sciences
• Research Group: MRC Virology
• Journal Name: Journal of General Virology
• Publisher: Society for General Microbiology
• ISSN: 0022-1317
• ISSN (Online): 1465-2099
• Copyright Holders: Copyright © 2009 The Authors
• First Published: First published in Journal of General Virology 90(1):69-73
• Publisher Policy: Reproduced under a Creative Commons License