Stokes, R.J., McKenzie, F., McFarlane, E., Ricketts, A., Tetley, L., Faulds, K., Alexander, J. and Graham, D. (2009) Rapid cell mapping using nanoparticles and SERRS. Analyst, 134(1), pp. 170-175. (doi: 10.1039/b815117b)
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Abstract
Bone marrow-derived immune cells (macrophages) treated with gold and silver nanoparticles before fixation and dye staining have been analysed by multiple wavelength line scanning surface enhanced resonance Raman scattering (SERRS) mapping. The method yields high selectivity and sensitivity within short analysis times, identifying nanoparticle aggregates in secondary lysosomes. Using routine cell stains, the output from fluorescence, Raman and SERRS is quantified at four wavelengths of excitation, demonstrating the potential at longer biologically compatible wavelengths of using nanoparticles with cell stains for superior cell mapping.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | McKenzie, Dr Fiona and Tetley, Dr Laurence and Faulds, Dr Karen |
| Authors: | Stokes, R.J., McKenzie, F., McFarlane, E., Ricketts, A., Tetley, L., Faulds, K., Alexander, J., and Graham, D. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Life Sciences |
| Journal Name: | Analyst |
| ISSN: | 0003-2654 |
| ISSN (Online): | 1364-5528 |
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