Thuita, J.K., Kagira, J.M., Mwangangi, D., Matovu, E., Turner, C.M.R. and Masiga, D. (2008) Trypanosoma brucei rhodesiense transmitted by a single tsetse fly bite in vervet monkeys as a model of human African trypanosomiasis. PLoS Neglected Tropical Diseases, 2(5), e238. (doi: 10.1371/journal.pntd.0000238)
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Publisher's URL: http://dx.doi.org/10.1371/journal.pntd.0000238
Abstract
Sleeping sickness is caused by a species of trypanosome blood parasite that is transmitted by tsetse flies. To understand better how infection with this parasite leads to disease, we provide here the most detailed description yet of the course of infection and disease onset in vervet monkeys. One infected tsetse fly was allowed to feed on each host individual, and in all cases infections were successful. The characteristics of infection and disease were similar in all hosts, but the rate of progression varied considerably. Parasites were first detected in the blood 4-10 days after infection, showing that migration of parasites from the site of fly bite was very rapid. Anaemia was a key feature of disease, with a reduction in the numbers and average size of red blood cells and associated decline in numbers of platelets and white blood cells. One to six weeks after infection, parasites were observed in the cerebrospinal fluid (CSF), indicating that they had moved from the blood into the brain; this was associated with a white cell infiltration. This study shows that fly-transmitted infection in vervets accurately mimics human disease and provides a robust model to understand better how sleeping sickness develops.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Turner, Professor Charles and Matovu, Dr Enock |
Authors: | Thuita, J.K., Kagira, J.M., Mwangangi, D., Matovu, E., Turner, C.M.R., and Masiga, D. |
College/School: | College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | PLoS Neglected Tropical Diseases |
Publisher: | Public Library of Science |
ISSN: | 1935-2727 |
ISSN (Online): | 1935-2735 |
Published Online: | 14 May 2008 |
Copyright Holders: | Copyright © 2008 The Authors |
First Published: | First published in PLoS Neglected Tropical Diseases 2(5):e238 |
Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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