Functionalisation of magnetic nanoparticles for applications in biomedicine

Berry, C.C. and Curtis, A.S.G. (2003) Functionalisation of magnetic nanoparticles for applications in biomedicine. Journal of Physics D: Applied Physics, 36(13), R198-R206. (doi:10.1088/0022-3727/36/13/203)

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Publisher's URL: http://dx.doi.org/10.1088/0022-3727/36/13/203

Abstract

Magnetic nanoparticles have been proposed for use as biomedical purposes to a large extent for several years. In recent years, nanotechnology has developed to a stage that makes it possible to produce, characterize and specifically tailor the functional properties of nanoparticles for clinical applications. This has led to various opportunities such as improving the quality of magnetic resonance imaging, hyperthermic treatment for malignant cells, site-specific drug delivery and the manipulation of cell membranes. To this end a variety of iron oxide particles have been synthesized. A common failure in targeted systems is due to the opsonization of the particles on entry into the bloodstream, rendering the particles recognizable by the body's major defence system, the reticulo-endothelial system. This review discusses each of the above bio-applications of such magnetic nanoparticles and details some of the main recent advances in biological research.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Curtis, Professor Adam and Berry, Dr Catherine
Authors: Berry, C.C., and Curtis, A.S.G.
Subjects:R Medicine > R Medicine (General)
Q Science > QH Natural history > QH345 Biochemistry
T Technology > TP Chemical technology
College/School:College of Medical Veterinary and Life Sciences
University Centres > Glasgow Materials Research Initiative
Journal Name:Journal of Physics D: Applied Physics
ISSN:0022-3727

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