Growth factor signaling permits hypoxia-induced autophagy by a HIF1 alpha-dependent, BNIP3/3L-independent transcriptional program in human cancer cells

Wilkinson, S. and Ryan, K.M. (2009) Growth factor signaling permits hypoxia-induced autophagy by a HIF1 alpha-dependent, BNIP3/3L-independent transcriptional program in human cancer cells. Autophagy, 5(7), pp. 1068-1069.

Abstract

Several recent reports have demonstrated that autophagy is induced in response to hypoxia in cultured cells. However, the mechanism and consequence of hypoxia-induced autophagy remains unclear as there is no consensus between these studies. In our recent report we show that, in human cancer cells, hypoxia cooperates with growth factor signaling to facilitate a HIF1 alpha-driven transcriptional response that promotes autophagy. Here we summarize these findings and set them in context of the findings of other groups, concluding that there are likely multiple routes to different forms of autophagy that serve different purposes downstream of hypoxia, depending upon the degree of stress and cellular context.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Ryan, Professor Kevin and Wilkinson, Dr Simon
• Authors: Wilkinson, S., and Ryan, K.M.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Autophagy
• ISSN: 1554-8627