Endocytic transport of integrins during cell migration and invasion

Caswell, P. and Norman, J. (2008) Endocytic transport of integrins during cell migration and invasion. Trends in Cell Biology, 18(6), pp. 257-263. (doi: 10.1016/j.tcb.2008.03.004)

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Publisher's URL: http://dx.doi.org/10.1016/j.tcb.2008.03.004


Early studies describing the endocytic-exocytic cycling of integrins prompted proposals that this process regulates cell migration. However, it is only relatively recently that more detailed descriptions of the molecular machinery responsible for directing integrin trafficking have enabled us to properly address the role of these events during the various modes of cell migration. Here, we review recent advances in our understanding of the protein complexes and signallosomes controlling integrin trafficking, and we describe how these influence cell migration and signalling events downstream of integrin engagement. Furthermore, we consider recent evidence for integrin trafficking during the invasive migration of cancer cells through 3D microenvironments, and conclude with a discussion of the use of novel photoactivatable integrin probes to visualize these processes.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Norman, Professor James and Caswell, Dr Patrick
Authors: Caswell, P., and Norman, J.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Trends in Cell Biology

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