Genomic amplicons target vesicle recycling in breast cancer

Mills, G.B., Jurisica, I., Yarden, Y. and Norman, J.C. (2009) Genomic amplicons target vesicle recycling in breast cancer. Journal of Clinical Investigation, 119(8), pp. 2123-2127. (doi:10.1172/JCI40256)

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Publisher's URL: http://dx.doi.org/10.1172/JCI40256

Abstract

Aberrant endocytosis, vesicle targeting, and receptor recycling represent emerging hallmarks of cancer. In this issue of the JCI, Zhang and colleagues demonstrate that RAB-coupling protein (RCP; also known as RAB11FIP1) is a "driver" of the 8p11-12 amplicon in human breast cancer and mouse xenograft models of mammary carcinogenesis (see the related article beginning on page 2171). Their finding that RAB GTPase function enables genomic amplification to confer aggressiveness to mammary tumors adds significantly to the body of evidence supporting pivotal roles for receptor trafficking in the proliferation and metastasis of cancer.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Norman, Professor James
Authors: Mills, G.B., Jurisica, I., Yarden, Y., and Norman, J.C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Journal of Clinical Investigation
ISSN:0021-9738

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