Integrins: masters and slaves of endocytic transport

Caswell, P.T., Vadrevu, S. and Norman, J.C. (2009) Integrins: masters and slaves of endocytic transport. Nature Reviews Molecular Cell Biology, 10(12), pp. 843-853. (doi:10.1038/nrm2799)

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Publisher's URL: http://dx.doi.org/10.1038/nrm2799

Abstract

Since it has become clear that adhesion receptors are trafficked through the endosomal pathway and that this can influence their function, much effort has been invested in obtaining detailed descriptions of the molecular machinery responsible for internalizing and recycling integrins. New findings indicate that integrin trafficking dictates the nature of Rho GTPase signalling during cytokinesis and cell migration. Furthermore, integrins can exert control over the trafficking of other receptors in a way that drives cancer cell invasion and tumour angiogenesis.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Vadrevu, Dr Suryakiran and Norman, Professor James and Caswell, Dr Patrick
Authors: Caswell, P.T., Vadrevu, S., and Norman, J.C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Nature Reviews Molecular Cell Biology
ISSN:1471-0072

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