Synthesis and antiproliferative evaluation of pyrazolo[1,5-a]-1,3,5-triazine myoseverin derivatives

Popowycz, F., Schneider, C., DeBonis, S., Skoufias, D.A., Kozielski, F., Galmarini, C.M. and Joseph, B. (2009) Synthesis and antiproliferative evaluation of pyrazolo[1,5-a]-1,3,5-triazine myoseverin derivatives. Bioorganic and Medicinal Chemistry, 17(9), pp. 3471-3478. (doi: 10.1016/j.bmc.2009.03.007)

Abstract

Pyrazolo[1,5-a]-1,3,5-triazine myoseverin derivatives 1a-c were prepared from 4-(N-methyl-N-phenylamino)2- methylsulfanylpyrazolo[1,5-a]-1,3,5-triazine 2. Their cytotoxic activity, inhibition of tubulin polymerization, and cell cycle effects were evaluated. Compounds 1a and 1c are potent tubulin inhibitors and displayed specific antiproliferative activity in colorectal cancer cell lines at micromolar concentrations.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Kozielski, Professor Frank
• Authors: Popowycz, F., Schneider, C., DeBonis, S., Skoufias, D.A., Kozielski, F., Galmarini, C.M., and Joseph, B.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Bioorganic and Medicinal Chemistry
• ISSN: 09680896