Chemotaxis in Dictyostelium: how to walk straight using parallel pathways

Insall, R. and Andrew, N. (2007) Chemotaxis in Dictyostelium: how to walk straight using parallel pathways. Current Opinion in Microbiology, 10(6), pp. 578-581. (doi: 10.1016/j.mib.2007.10.004)

Abstract

Dictyostelium is one of the most successful and best-studied organisms for research into the mechanisms that drive chemotaxis. In this review, we discuss recent progress in the field. Phosphatidylinositol 3-kinase (PI 3-kinase), previously thought by some to be essential for chernotaxis, has now been proven to be dispensable. However, other pathways are emerging which might connect signalling to migration. In particular, phospholipase A2 homologues appear to play an important role. Other areas of current interest include the fundamental processes by which cells move - pseuclopods have been found to be generated in many different ways. Similarly, chernotaxis may be mediated by multiple checks on the number of pseuclopods, rather than by simple generation of new pseuclopods on demand. Finally, we review several advances in the theory of how cells convert shallow, noisy chemical gradients into overt movement.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Insall, Professor Robert
• Authors: Insall, R., and Andrew, N.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Current Opinion in Microbiology
• ISSN: 13695274