Insall, R. H. (2010) Understanding eukaryotic chemotaxis: a pseudopod-centred view. Nature Reviews Molecular Cell Biology, 11(6), pp. 453-458. (doi: 10.1038/nrm2905)
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Publisher's URL: http://dx.doi.org/10.1038/nrm2905
Abstract
Current descriptions of eukaryotic chemotaxis and cell movement focus on how extracellular signals (chemoattractants) cause new pseudopods to form. This 'signal-centred' approach is widely accepted but is derived mostly from special cases, particularly steep chemoattractant gradients. I propose a 'pseudopod-centred' explanation, whereby most pseudopods form themselves, without needing exogenous signals, and chemoattractants only bias internal pseudopod dynamics. This reinterpretation of recent data suggests that future research should focus on pseudopod mechanics, not signal processing.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Insall, Professor Robert |
| Authors: | Insall, R. H. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Nature Reviews Molecular Cell Biology |
| Publisher: | Nature Publishing Group |
| ISSN: | 1471-0072 |
| ISSN (Online): | 1471-0080 |
| Published Online: | 06 May 2010 |
| Related URLs: |
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