Gonzalvez, F., Schug, Z.T., Houtkooper, R. H., MacKenzie, E. D., Brooks, D. G., Wanders, R. J.A., Petit, P. X., Vaz, F. M. and Gottlieb, E. (2008) Cardiolipin provides an essential activating platform for caspase-8 on mitochondria. Journal of Cell Biology, 183(4), pp. 681-696. (doi: 10.1083/jcb.200803129)
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Abstract
Cardiolipin is a mitochondria-specific phospholipid known to be intimately involved with apoptosis. However, the lack of appropriate cellular models to date restricted analysis of its role in cell death. The maturation of cardiolipin requires the transacylase tafazzin, which is mutated in the human disorder Barth syndrome. Using Barth syndrome patient-derived cells and HeLa cells in which tafazzin was knocked down, we show that cardiolipin is required for apoptosis in the type II mitochondria-dependent response to Fas stimulation. Cardiolipin provides an anchor and activating platform for caspase-8 translocation to, and embedding in, the mitochondrial membrane, where it oligomerizes and is further activated, steps that are necessary for an efficient type II apoptotic response.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Gottlieb, Professor Eyal |
| Authors: | Gonzalvez, F., Schug, Z.T., Houtkooper, R. H., MacKenzie, E. D., Brooks, D. G., Wanders, R. J.A., Petit, P. X., Vaz, F. M., and Gottlieb, E. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Journal of Cell Biology |
| ISSN: | 0021-9525 |
| ISSN (Online): | 1540-8140 |
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