Vousden, K. and Lu, X. (2002) Live or let die: the cell's response to p53. Nature Reviews Cancer, 2(8), pp. 594-604. (doi: 10.1038/nrc864)
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Publisher's URL: http://dx.doi.org/10.1038/nrc864
Abstract
Compared with many normal tissues, cancer cells are highly sensitized to apoptotic signals, and survive only because they have acquired lesions - such as loss of p53 - that prevent or impede cell death. We are now beginning to understand the complex mechanisms that regulate whether or not a cell dies in response to p53 - insights that will ultimately contribute to the development of therapeutic strategies to repair the apoptotic p53 response in cancers.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Vousden, Karen |
| Authors: | Vousden, K., and Lu, X. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Nature Reviews Cancer |
| ISSN: | 1474175X |
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