Vousden, K. and Ryan, K. (2009) p53 and metabolism. Nature Reviews Cancer, 9(10), pp. 691-700. (doi: 10.1038/nrc2715)
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Publisher's URL: http://dx.doi.org/10.1038/nrc2715
Abstract
Although metabolic alterations have been observed in cancer for almost a century, only recently have the mechanisms underlying these changes been identified and the importance of metabolic transformation realized. p53 has been shown to respond to metabolic changes and to influence metabolic pathways through several mechanisms. The contributions of these activities to tumour suppression are complex and potentially rather surprising: some reflect the function of basal p53 levels that do not require overt activation and others might even promote, rather than inhibit, tumour progression.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Ryan, Professor Kevin and Vousden, Karen |
| Authors: | Vousden, K., and Ryan, K. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Nature Reviews Cancer |
| ISSN: | 1474-175X |
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