In vitro osteoblastic response to 30vol % hydroxyapatite polyethylene composite

Zhang, Y., Tanner, K.E. , Gurav, N. and Di Silvio, L. (2007) In vitro osteoblastic response to 30vol % hydroxyapatite polyethylene composite. Journal of Biomedical Materials Research Part A, 81A(2), pp. 409-417. (doi: 10.1002/jbm.a.31078)

Abstract

Hydroxyapatite-reinforced high-density polyethylene (HA-HDPE) composite, as a bone replacement material, has successfully been used clinically as middle ear prostheses and orbital floor implants. The aim of this study was to examine its in vitro biocompatibility in order to develop a further application, that is, as skull reconstruction implants. Human osteoblast cells isolated from femoral heads and crania were used to determine the biological response of the composites. HA-HDPE composites (30 vol %) with two grades of HA filler that had different surface morphologies were selected for this in vitro assessment. The results showed that HA-HDPE composite was bioactive and supported osteoblast attachment, proliferation, and differentiation. The composite with rough-surfaced HA filler demonstrated slightly better cellular response than the composite with smooth-surfaced HA filler. Although osteoblastic cells derived from skull showed an overall slower response compared with those from femoral heads, these in vitro results show that HA-HDPE composite potentially could be used as a skull implant.

• Item Type: Articles
• Keywords: composite; in vitro; osteoblast; cranial osteoblast; particle surface morphology; hydroxyapatite; polyethylene
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Tanner, Professor Kathleen
• Authors: Zhang, Y., Tanner, K.E., Gurav, N., and Di Silvio, L.
• Subjects: R Medicine > RD Surgery; T Technology > T Technology (General)
• College/School: College of Science and Engineering > School of Engineering > Biomedical Engineering
• Journal Name: Journal of Biomedical Materials Research Part A
• ISSN: 1552-4965