Biocompatibility of a lab-on-a-pill sensor in artificial gastrointestinal environments

Johannessen, E.A., Wang, L., Wyse, C., Cumming, D.R.S. and Cooper, J.M. (2006) Biocompatibility of a lab-on-a-pill sensor in artificial gastrointestinal environments. IEEE Transactions on Biomedical Engineering, 53(11), pp. 2333-2340. (doi: 10.1109/TBME.2006.883698)

Abstract

n this paper, we present a radiotelemetry sensor, designed as a lab-in-a-pill, which incorporates a two-channel microfabricated sensor platform for real-time measurements of temperature and pH. These two parameters have potential application for use in remote biological sensing (for example they may be used as markers that reflect the physiological environment or as indicators for disease, within the gastrointestinal tract). We have investigated the effects of biofouling on these sensors, by exploring their response time and sensitivity in a model in vitro gastrointestinal system. The artificial gastric and intestinal solutions used represent a model both for fasting, as well as for the ingestion of food and subsequent digestion to gastrointestinal chyme. The results showed a decrease in pH sensitivity after exposure of the sensors for 3 h. The response time also increased from an initial measurement time of 10 s in pure GI juice, to ca. 25 s following the ingestion of food and 80 s in simulated chyme. These in vitro results indicate that changes in viscosity in our model gastrointestinal system had a pronounced effect on the unmodified sensor.

• Item Type: Articles
• Keywords: Biofouling, in vitro measurements, lab-in-a-pill, microfabricated sensors, radiotelemetry.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Cumming, Professor David and Wyse, Dr Cathy
• Authors: Johannessen, E.A., Wang, L., Wyse, C., Cumming, D.R.S., and Cooper, J.M.
• Subjects: R Medicine > R Medicine (General); T Technology > T Technology (General)
• College/School: College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering; College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
• Journal Name: IEEE Transactions on Biomedical Engineering
• Publisher: IEEE
• ISSN: 0018-9294
• Copyright Holders: Copyright © 2006 IEEE
• First Published: First published in IEEE Transactions on Biomedical Engineering 53(11):2333-2340
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher.