Direct stimulation of translation by the multifunctional herpesvirus ICP27 protein

Larralde, O., Smith, R., Wilkie, G., Malik, P., Gray, N.K. and Clements, J.B. (2006) Direct stimulation of translation by the multifunctional herpesvirus ICP27 protein. Journal of Virology, 80(3), pp. 1588-1591.

Abstract

Herpes simplex virus type 1 (HSV-1) ICP27 protein is an essential regulator of viral gene expression with roles at various levels of RNA metabolism in the nucleus. Using the tethered function assay, we showed a cytoplasmic activity for ICP27 in directly enhancing mRNA translation in vivo in the absence of other viral factors. The region of ICP27 required for translational stimulation maps to the C terminus. Furthermore, in infected cells, ICP27 is associated with polyribosomes, indicating a function in translation during the lytic cycle.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Wilkie, Dr Gavin
• Authors: Larralde, O., Smith, R., Wilkie, G., Malik, P., Gray, N.K., and Clements, J.B.
• Subjects: Q Science > QR Microbiology > QR180 Immunology
• College/School: College of Medical Veterinary and Life Sciences
• Journal Name: Journal of Virology
• Journal Abbr.: J. Virol.
• ISSN: 0022-538X
• ISSN (Online): 1098-5514

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
38031	1	A family of multifunctional proteins that orchestrates RNA metabolism in herpesvirus infected cells	Sheila Graham	Medical Research Council (MRC)	G9826324	Centre for Virus Research